Release of Catecholamines and Specific Protein from Adrenal Glands

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Science  28 Oct 1966:
Vol. 154, Issue 3748, pp. 529-531
DOI: 10.1126/science.154.3748.529


Rabbit antiserums directed against a purified protein obtained from the catecholamine storage vesicles of the adrenal medulla of the cow were used to study the mechanism of secretion from the adrenal medulla. During secretion evoked by acetylcholine in isolated perfused adrenal glands, catecholamines and the specific intravesicular protein were released in relative amounts comparable to those present in the intact gland. Thus catecholamines are apparently released from the storage vesicles by a process resembling reverse pinocytosis.

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