Multiple Sclerosis: Correlaion between lImmunoglobulin-G in Cerebrospinal Fluid and Brain

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Science  25 Nov 1966:
Vol. 154, Issue 3752, pp. 1044-1046
DOI: 10.1126/science.154.3752.1044


There is a positive correlation between the concentration of immunoglobulin-G in plaques of demyelination due to multiple sclerosis (as well as in white matter of normal appearance) and the concentration of this globulin in the cerebrospinal fluid. The tentative conclusion drawn from these results was that, in patients with multiple sclerosis, the increase in immuno-globulin-G in the cerebrospinal fluid is a reflection of an excess of this globulin in the brain.