Vesicular Stomatitis Virus Replication in Human Leukocyte Cultures: Enhancement by Phytohemagglutinin

See allHide authors and affiliations

Science  25 Nov 1966:
Vol. 154, Issue 3752, pp. 1053-1055
DOI: 10.1126/science.154.3752.1053


The replication of vesicular stomatitis virus in human leukocyte cultures shows that virus yields can be enhanced 6-to 180-fold by treating the leukocyte cultures with phytohemagglutinin prior to virus inoculation. Data suggest that a substance is produced in phytohemagglutinin-treated leukocyte cultures which is capable, on transfer to fresh leukocytes, of inducing blast cell formation and enhancing virus replication.