Segregation of Sister Chromatids in Mammalian Cells

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Science  02 Dec 1966:
Vol. 154, Issue 3753, pp. 1202-1205
DOI: 10.1126/science.154.3753.1202


Segregation of sister chromatids in embryonic mouse cells in primary tissue culture is not random. In mitosis those chromatids replicated on a DNA template synthesized during the preceding division cycle are separated from those constructed on a template synthesized two division cycles previously. Segregation in cells of the Chinese hamster follows a similar, but less pronounced, pattern.

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