Deficits in Passive Avoidance and Fear Conditioning in Mice with Septal Lesions

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Science  02 Dec 1966:
Vol. 154, Issue 3753, pp. 1207-1208
DOI: 10.1126/science.154.3753.1207


By means of a simple activity measure, mice with lesions of the septal forebrain were tested for passive avoidance (response inhibition) and fear conditioning. In two separate experiments animals with septal lesions showed little or no conditioning, as evidenced by lack of suppression of activity during and following activitycontingent foot shock. Results support and extend thehypothesis that these deficits in passive avoidance derive from the removal of normal inhibitory influences mediated by the septal area.