Puromycin and Cycloheximide: Different Effects on Hippocampal Electrical Activity

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Science  23 Dec 1966:
Vol. 154, Issue 3756, pp. 1557-1558
DOI: 10.1126/science.154.3756.1557


Abstract. Mice were injected in the temporal region of the brain with cycloheximide or puromycin; both agents markedly inhibit protein synthesis in the brain. Recordings of electrical activity were made in the hippocampal region 5 hours after injection of these drugs. The amplitude and frequency observed in records from mice injected with cycloheximide were indistinguishable from those injected with saline alone. Records from puromycin-injected mice were strikingly abnormal. This finding may contribute to the differences in behavioral effects of intracerebral injections of the two inhibitors of protein synthesis studied.