Control of the Activity of Escherichia coli Carbamoyl Phosphate Synthetase by Antagonistic Allosteric Effectors

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Science  23 Dec 1966:
Vol. 154, Issue 3756, pp. 1572-1573
DOI: 10.1126/science.154.3756.1572


The synthesis of carbamoyl phosphate required in both arginine and pyrimidine biosyntheses is carried out by a single enzyme in Escherichia coli. Opposed effects of pyrimidine nucleotides and of ornithine on the activity of the enzyme ensure a proper supply of carbamoyl phosphate according to the needs of the two biosynthetic sequences.