Metabolism of Rotenone in vitro by Tissue Homogenates from Mammals and Insects

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Science  10 Feb 1967:
Vol. 155, Issue 3763, pp. 713-716
DOI: 10.1126/science.155.3763.713


Hydroxylation of rotenone in vitro in the enzyme system composed of microsomes and reduced nicotinamide-adenine dinucleotide phosphate, and in living mice and houseflies, yields products tentatively identified as rotenolone I; rotenolone II; 8'-hydroxyrotenone; 6',7'-dihydro-6',7'-dihydroxyrotenone; two rotenolones of each of the last-mentioned two compounds; and uncharacterized polar materials. The toxicity of certain of these rotenoids to mice is of the same order as that of rotenone.