Disruption of Hibernation Caused by Hypothalamic Lesions

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Science  24 Feb 1967:
Vol. 155, Issue 3765, pp. 1031-1033
DOI: 10.1126/science.155.3765.1031


Lesions were made in the preoptic-anterior hypothalamic area or ventromedial nucleus of ground squirrels (Citellus tridecemlineatus). Four squirrels, two with preoptic damage and two obese hyperphagics, entered hibernation within 1 to 3 days. They all died after 11 to 12 days, shortly after all normal hibernating squirrels had awakened. Seven squirrels with preoptic damage, rendered hypothermic before being placed in the cold, died within 2 to 6 days.