Phenylketonuria: Enduring Behavioral Deficits in Phenylketonuric Rats

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Science  24 Feb 1967:
Vol. 155, Issue 3765, pp. 1033-1035
DOI: 10.1126/science.155.3765.1033


The behavioral deficit in rats made "phenylketonuric" by ingestion of L-phenylalanine was evaluated 23 to 65 days following cessation of treatment. Animals treated from birth to 60 days showed significant deficit on reasoning and discrimination learning tests but not on discrimination reversal sets. Animals treated from 30 to 60 days showed significant deficit only on the reasoning test.