Flaxedil (Gallamine Triethiodide): Evidence for a Central Action

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Science  31 Mar 1967:
Vol. 155, Issue 3770, pp. 1685-1687
DOI: 10.1126/science.155.3770.1685


A central action of gallamine triethiodide has been demonstrated in cats with permanently implanted electrodes that permit direct repetitive stimulation and recording of afterdischarges from cerebral cortex. Systemically administered gallamine produced a consistent and reproducible augmentation of duration of afterdischarge at doses just sufficient to produce skeletal muscle paralysis. Simultaneous examination of expiratory carbon dioxide, blood pressure, body temperature, blood glucose, and direct cortical response to brief single stimuli failed to reveal any consistent peripheral change to which the centrally observed effecte Could be attributed.

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