Serotonin: Release in the Forebrain by Stimulation of Midbrain Raphé

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Science  21 Apr 1967:
Vol. 156, Issue 3773, pp. 402-403
DOI: 10.1126/science.156.3773.402


Electrical stimulation of the midbrain raphé, an area in which neuronal perikarya containing serotonin are aggregated, produces an increase in 5-hydroxyindoleacetic acid and a decrease in serotonin in the forebrain. These changes indicate that serotonin in the brain can be released via a specific neural pathway, namely, the system of axons projecting into the forebrain from serotonin-containing neurons in the midbrain raphé.

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