Human Fibroblasts Infected with Rubella Virus Produce a Growth Inhibitor

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Science  05 May 1967:
Vol. 156, Issue 3775, pp. 659-661
DOI: 10.1126/science.156.3775.659


A protein that inhibited mitosis of normal human diploid cells was demonstrated in extracts of WI-38 cells that were infected with rubella virus and that had gone into mitotic arrest subsequent to infection. A possible mechanism for the pathogenesis of the rubella syndrome is suggested.