Pyrimidine Nucleotide Synthesis: Regulatory Control during Transformation of Lymphocytes in vitro

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Science  02 Jun 1967:
Vol. 156, Issue 3779, pp. 1237-1240
DOI: 10.1126/science.156.3779.1237


The incorporation of uridine into RNA in lymphocytes undergoing transformation induced by phytohemagglutinin parallels its incorporation into the intratcellular pool of acid-soluble nucleotides and coincides with a 20-fold increase in the specific activity of uridine kinase. This increase is dependent upon synthesis of both RNA and protein and is subject to both repression and end-product inhibition by cytidine.

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