Lactones as Inhibitors of the Fibrinolytic System

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Science  02 Jun 1967:
Vol. 156, Issue 3779, pp. 1244-1245
DOI: 10.1126/science.156.3779.1244


Caprolactone, valerolactone, and butyrolactone inhibit proteolytic and fibrinolytic activities of human plasmin. In very low concentrations, they also inhibit activation of plasminogen through plasmin-streptokinase activator and human urokinase. The degree of inhibitory potency depends upon the number of carbon atoms in the lactone.

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