Antigenic Competition: Cellular or Humoral

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Science  27 Oct 1967:
Vol. 158, Issue 3800, pp. 512-514
DOI: 10.1126/science.158.3800.512


The injection of one antigen into mice inhibited the response to a second when 1 to 10 days separated the two injections. When the same type of inhibition was attempted in γ-irradiated mice reconstituted with normal spleen cells, the inhibition was greater in mice receiving 50 million spleen cells than in those receiving 10 million. The results are interpreted as favoring a humoral mechanism of inhibition.

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