Chromosome Abnormality in Rat Leukemia Induced by 7,12-Dimethylbenz[a]anthracene

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Science  24 Nov 1967:
Vol. 158, Issue 3804, pp. 1058-1059
DOI: 10.1126/science.158.3804.1058


A high percentage of consistent chromosome abnormality, trisomy of the longest telocentric chromosome, was found in leukemias induced in rats of the Long-Evans strain by pulse doses of 7,12-dimethylbenz[a]anthracene. Cells with this abnormality were large, immature, and mononuclear and tended toward erythroblastic maturation.