Murine Lymphoma: Augmented Growth in Mice with Pertussis Vaccine-Induced Lymphocytosis

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Science  24 Nov 1967:
Vol. 158, Issue 3804, pp. 1061-1064
DOI: 10.1126/science.158.3804.1061


Injection of Bordetella pertussis vaccine caused an excessive lymphocytosis, associated with an augmented growth of a lymphoma cell homotransplant in mice. A markedly impaired reactive cell proliferation was revealed in the spleens of the vaccine-pretreated mice after stimulation with phytohemagglutinin or Freund's complete adjuvant.