Acyl Carrier Protein: Effects of Acetylation and Tryptic Hydrolysis on Function in Fatty Acid Synthesis

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Science  26 Jan 1968:
Vol. 159, Issue 3813, pp. 428-430
DOI: 10.1126/science.159.3813.428


Acetylation of the four lysine residues and the amino group of the terminal serine residue of Escherichia coli acyl carrier protein has no effect on the ability of this protein to function in fatty acid synthesis. Subsequent trypsin hydrolysis resulting in complete inactivation cleaves a single arginyl peptide bond, releasing the amino terminal hexapeptide from the molecule.