Specific Inhibition of Viral Ribonucleic Acid Replication by Gliotoxin

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Science  26 Jan 1968:
Vol. 159, Issue 3813, pp. 431-432
DOI: 10.1126/science.159.3813.431


Gliotoxin inhibits intracellular replication of poliovirus in HeLa cells at a stage subsequent to adsorption and penetration of virus. The sensitive step is synthesis of viral RNA: synthesis of viral protein is unaffected except as a consequence of blockade of RNA synthesis. Concentrations of gliotoxin sufficient to block viral RNA synthesis completely do not affect cellular RNA synthesis.