Parathyroid Hormone Production in vitro by Human Parathyroid Cells Transformed by Simian Virus 40

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Science  26 Jan 1968:
Vol. 159, Issue 3813, pp. 435-436
DOI: 10.1126/science.159.3813.435


Cells froma human parathyroid adenoma were infected with simian virus 40 and maintained through 13 subcultures in monolayer tissue culture. For more than 9 months, these "transformed" cells contimed to produce parathyroid hormone which was identified by radioimmunoassay and density-gradient ultra centrifugation.