Transformation of Human Lymphocytes: Inhibition by Homologous Alpha Globulin

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Science  15 Mar 1968:
Vol. 159, Issue 3820, pp. 1243-1244
DOI: 10.1126/science.159.3820.1243


An alpha globulin fraction prepared from normal human plasma by column chromatography prevents homologous lymphocyte transformation and the stimulation of DNA, and also protein synthesis induced by phytohemagglutinin and specific antigens. These observations support the concept of a normal circulating immunosuppressant factor which prevents lymphoid cell proliferation.

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