Concanavalin A in vivo: Induction of Hemorrhagic Skin Lesions (Arthus-Like Reactions) in Mice

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Science  19 Apr 1968:
Vol. 160, Issue 3825, pp. 312-313
DOI: 10.1126/science.160.3825.312


Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if concanavalin A was adsorbed with insoluble a2- macroglobulin or if mice were first treated with nitrogen mustard. The ability of concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.

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