Actinomycin D: Inhibition of Phospholipid Synthesis in Chick Embryo Cells

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Science  19 Apr 1968:
Vol. 160, Issue 3825, pp. 316-317
DOI: 10.1126/science.160.3825.316


When chick embryo fibroblasts are exposed to actinomycin D for 30 minutes to 3 hours, there is progressive inhibition of phospholipid synthesis, so that by 3 hours the inhibition is 40 percent. All phospholipids are affected. Since this inhibition is twice as great as the inhibition of protein synthesis, some effects of actinomycin D previously ascribed to decreased protein synthesis must be reevaluated.

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