Melanocyte-Stimulating Hormone: Activity in Thermal Polymers of Alpha-Amino Acids

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Science  03 May 1968:
Vol. 160, Issue 3827, pp. 547-548
DOI: 10.1126/science.160.3827.547


Thermal polymers of arginine, glutamic acid, glycine, histidine, phenylalanine, and tryptophan have melanocyte-stimulating activity. The fact that similar polymers lack such activity indicates that the effect is related to the specific amino acid residues. The active polymers are discussed as a model of an evolutionary precursor of contemporary melanocyte-stimulating hormone.

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