Fetal Hemoglobin Variants in Mice

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Science  24 May 1968:
Vol. 160, Issue 3830, pp. 885-886
DOI: 10.1126/science.160.3830.885


Two strains of mice, DBA and C3H, have a fetal globin polypeptide chain which differs in electrophoretic mobility from the corresponding fetal chain of the C57B1 strain. Mice of the DBA and C3H strains also differ from those of the C57B1 in adult hemoglobin type. Results of backcrossing the (DBA x C57B1) hybrid to the C57B1 suggest that the fetal chain locus and the adult β-chain locus are closely linked.

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