Ouabain and Streptomycin: Their Different Loci of Action on Saccular Hair Cells in Goldfish

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Science  07 Jun 1968:
Vol. 160, Issue 3832, pp. 1117-1119
DOI: 10.1126/science.160.3832.1117


Ouabain, when applied to the periotic spaces, that is, to the basal end of the saccular hair cells, suppressed microphonic potentials of the inner ear in goldfish. In contrast, streptomycin produced such an effect only when it was applied directly into the endolymph, that is, to the hair-bearing ends of the hair cells.

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