Motor Effects of Copper in the Caudate Nucleus: Reversible Lesions with Ion-Exchange Resin Beads

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Science  14 Jun 1968:
Vol. 160, Issue 3833, pp. 1237-1239
DOI: 10.1126/science.160.3833.1237


A method employing the use of ion-exchange resin beads is described for the punctate introduction of discrete amounts of various anions, cations, or zwitterions into given brain regions. A series of experiments utilizing the method to introduce ionic copper into the caudate nucleus with the resulting motor manifestations are discussed.

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