Secretory Immunoglobulin A: Autoantibody Activity in Gastric Juice

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Science  14 Jun 1968:
Vol. 160, Issue 3833, pp. 1240-1241
DOI: 10.1126/science.160.3833.1240


An immunoglobulin A of the secretory variety, present in the gastric juice of a patient with pernicious anemia, was shown to have specificity for intrinsic factor. This is the first demonstration in gastric juice of antibody activity restricted to secretory IgA; further, this is the first example of an exocrine (gastric) immune system producing an autoantibody specifically directed toward a product synthesized by that same exocrine organ.

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