LSD in Mice: Abnormalities in Meiotic Chromosomes

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Science  14 Jun 1968:
Vol. 160, Issue 3833, pp. 1246-1248
DOI: 10.1126/science.160.3833.1246


Meiotic chromosomes of six mice injected with high doses of lysergic acid diethylamide (LSD-25) and of six controls were studied. Several breaks, gaps, and unidentifiable fragments were found in the treated but, with a few exceptions, not in the control animals. Secondary constrictions were more numerous in the treated than in the untreated mice. Possible consequences are discussed.

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