Photodimer of Thymine in Ultraviolet-Irradiated DNA: Proof of Structure by X-ray Diffraction

See allHide authors and affiliations

Science  28 Jun 1968:
Vol. 160, Issue 3835, pp. 1451-1452
DOI: 10.1126/science.160.3835.1451


Dimethylthymine was photodimerized with ultraviolet radiation, and the structure of one of the resulting dimers, the cis 5,5 : 6,6 isomer, was determined by single-crystal x-ray diffraction. This isomer is the same as that obtained by ultraviolet irradiation of DNA; hence the structure of the thymine dimer in irradiated DNA is now proved.

Stay Connected to Science