Rejection of Renal Allografts: Specific Immunologic Suppression

See allHide authors and affiliations

Science  28 Jun 1968:
Vol. 160, Issue 3835, pp. 1463-1465
DOI: 10.1126/science.160.3835.1463


Kidneys were transplanted across a major genetic barrier (Ag-B locus), from LewisxBN F1 hybrid rats into bilaterally nephrectomized Lewis rats. Survival of grafts is prolonged (indefinite?) in rats treated with a combination of (i) intravenous injection of donor spleen cells 1 day before the graft, and (ii) passive immunization with antiserum prepared in rats of the recipient strain against donor spleen and lymph-node cells. The recipient's immune response to other antigens is not impaired.

Stay Connected to Science