Behavioral Effects in Monkeys of Racemates of Two Biologically Active Marijuana Constituents

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Science  28 Jun 1968:
Vol. 160, Issue 3835, pp. 1467-1469
DOI: 10.1126/science.160.3835.1467


Both dl-Δ8- and dl-Δ9-tetrahydrocannabinol produced marked alterations of behavior in rhesus and squirrel monkeys. Squirrel monkeys appeared to have visual hallucinations. Continuous avoidance behavior of squirrel monkeys was stimulated by both drugs, but high doses of dl-Δ9-tetrahydrocannabinol also caused depression after the stimulant phase. Complex behavior involving memory and visual discrimination in rhesus monkeys was markedly disrupted by both drugs.

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