Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin

See allHide authors and affiliations

Science  28 Jun 1968:
Vol. 160, Issue 3835, pp. 1469-1471
DOI: 10.1126/science.160.3835.1469


Preference for ethyl alcohol was significantly reduced or totally abolished in rats given orally p-chlorophenylalanine, a tryptophan hydroxylase inhibitor that selectively depletes brain serotonin. Some aversion to alcohol was observed while p-chlorophenylalanine was administered, but the rats' rejection of alcohol was even more marked after the drug was discontinued. Oral administration of α-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor that depletes brain catecholamines, slightly reduced selection of alcohol, but preference returned to normal as soon as α-methyl-p-tyrosine was terminated.

Stay Connected to Science