5-Diazo-4-Oxo-L-Norvaline: Reactive Asparagine Analog with Biological Specificity

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Science  05 Jul 1968:
Vol. 161, Issue 3836, pp. 62-63
DOI: 10.1126/science.161.3836.62


The L-asparagine analog, 5-diazo-4-oxo-L-norvaline, specifically inactivates L-asparaginase and inhibits the growth of L-asparagine-dependent or L-asparaginase-sensitive tumor cells in culture. With 5-14C-labeled compound, a biphasic incorporation into sensitive cells occurs, but the inhibition of cell multiplication is manifest much later than the rapid phase of incorporation of the analog.

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