Prebiotic Synthesis: Phosphorylation in Aqueous Solution

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Science  05 Jul 1968:
Vol. 161, Issue 3836, pp. 64-66
DOI: 10.1126/science.161.3836.64


Formation of uridine-5'-phosphate from uridine and inorganic phosphate in aqueous solution is effected by the following condensing agents: cyanogen, cyanoformamide, cyanate, cyanamide, thioformate, ethylisocyanide, and a watersoluble carbodiimide. The yields are always small, even when a large excess of condensing agent is used. The cyclization of uridine-3'-(2')-phosphate occurs under the same conditions but in much greater yield.

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