Lymphocytes: Circulation Altered by Trypsin

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Science  12 Jul 1968:
Vol. 161, Issue 3837, pp. 176-178
DOI: 10.1126/science.161.3837.176


Rat thoracic duct lymphocytes altered by trypsin in vitro do not circulate normally. At early intervals after transfusion of lymphocytes labeled with chromium-51 selective accumulation of radioactivity in the lymph nodes is abolished, while uptake in the spleen is not reduced. Later, the cells appear to "home" to lymph nodes and recirculate to the lymph.

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