Cytodifferentiation during Insect Metamorphosis: The Galea of Silkmoths

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Science  02 Aug 1968:
Vol. 161, Issue 3840, pp. 470-472
DOI: 10.1126/science.161.3840.470


In the galea of silkmoths undergoing metamorphosis, generalized epidermal cells, which had previousty secreted pupal cuticle, transform into highly specialized cells producing a new protein, the enzyme cocoonase. These cells first segregate by mitosis and displacement, then grow rapidly through endomitosis and accumulation of RNA-rich cytoplasm, and finally begin rapid synthesis of cocoonase. Replication of DNA continues in fully differentiated cells synthesizing cocoonase.

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