Temperature in the Monkey: Transmitter Factors Released from the Brain during Thermoregulation

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Science  09 Aug 1968:
Vol. 161, Issue 3841, pp. 572-573
DOI: 10.1126/science.161.3841.572


When perfusate is collected from the anterior hypothalamus of a cooled donor monkey and is transfused to a corresponding hypothalamic site in a normal monkey, fever occurs in this recipient. Conversely, perfusate from a heated donor monkey lowers the recipient monkey's temperature when the same hypothalamic transfusion procedure is followed. These experiments provide direct evidence of a neurochemical "coding" within the specific anatomical region of the brain historically implicated in the control of body temperature.

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