Beta Thalassemia Trait: Detection at Birth

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Science  09 Aug 1968:
Vol. 161, Issue 3841, pp. 589-590
DOI: 10.1126/science.161.3841.589


The synthesis of alpha, beta, and gamma chains in samples of cord blood was measured by the incorporation of leucine labeled with carbon-14 into these chains. In a newborn affected with beta thalassemia trait, the presence of one beta thalassemia gene was revealed on the 1st day of life by the lower specific radioactivity of the beta chain.