Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe

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Science  16 Aug 1968:
Vol. 161, Issue 3842, pp. 706-708
DOI: 10.1126/science.161.3842.706


Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased metabolism of serotonin produced by this drug.

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