Histamie Release in vitro: Inhibition by Catecholamines and Methylxanthines

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Science  30 Aug 1968:
Vol. 161, Issue 3844, pp. 902-903
DOI: 10.1126/science.161.3844.902


Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes. They act synergistically to inhibit the reaction, but must be present when antigen is added; preincubation is not effective. Since both increase cellular levels of cyclic 3 ', 5'-adenosine monophosphate it is postulated that this compound plays a role in the regulation of allergic histamine release.

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