Lupus Nephritis: Varying Complement-Fixing Properties of Immuvnoglobulin G Antibodies to Antigens of Cel Nuclei

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Science  30 Aug 1968:
Vol. 161, Issue 3844, pp. 904-906
DOI: 10.1126/science.161.3844.904


Relative complement-fixing activity of antibodies to nuclear antigens, including DNA, were determined in serums of 15 patients with, and 65 patients without, active lupus nephritis, by comparing titers obtained in two methods. High complement-fixing activity of antibody was found in the nephritis group and low activity in the others. Results with immunoglobulin G fractions were similar.

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