Oncogenicity by Methyl Methanesulfonate in Male RF Mice

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Science  30 Aug 1968:
Vol. 161, Issue 3844, pp. 913-914
DOI: 10.1126/science.161.3844.913


The incidences of lung tumors and thymic lymphomas were increased in young adult male RF mice receiving 30 milligrams of methyl meth anesulfonate per kilogram of body weight daily in the drinking water throughout life. Differences in oncogenicity between treatment with methyl methanesulfonate and with dimethylnitrosamine or diethylnitrosamine suggest a qualitative difference between the site (or sites) of alkylation by methyl methanesulfonate and by dimethylnitrosamine or diethylnitrosamine within the nucleic acids.

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