Thiobases in Escherchia coli Transfer RNA: 2-Thiocytosine and 5-Methylaminomethyl-2-thiouracil

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Science  13 Sep 1968:
Vol. 161, Issue 3846, pp. 1146-1147
DOI: 10.1126/science.161.3846.1146


Two new sulfur-containing pyrimidine nucleotides have been isolated from hydrolyzates of Escherichia coli transfer RNA. The structures, 2-thiocytosine and 5-methylaminomethyl-2-thiouracil, have been assigned to the bases as a result of study of ultraviolet and mass spectra. An acid-degradation product, S-methylamino-methyluracil, has been synthesized and is identical to that derived from the natural product.

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