Allergic Encephalomyelitis: Passive Transfer Prevented by Encephalitogen

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Science  13 Sep 1968:
Vol. 161, Issue 3846, pp. 1155-1157
DOI: 10.1126/science.161.3846.1155


Allergic encephalomyelitis was produced in rats by passive transfer of lymph node cells from donors immunized intradernmally with nleural tissute or an encephalitogenic basic protein pluts adjulvants. The same basic protein, injected intravenously into the recipients before or after transfer of lymph node cells, prevented the disease. Even established lesions were reversed. Inhibition by basic protein was specific for encephalomyelitis; it had no effect onz passive transfer of allergic adrenalitis.

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