Antibodies to Deoxyribonucleic Acid Irradiated with Ultraviolet Light: Detection by Precipitins and Immunofluorescence

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Science  27 Sep 1968:
Vol. 161, Issue 3848, pp. 1353-1354
DOI: 10.1126/science.161.3848.1353


Two rabbits were immunized with a complex consisting of ultravioietirradiated DNA and methylated bovine serum albumin. Serum antibodies reacted only with irradiated DNA, and the serological reaction was shown by immuneprecipitation and immunofluorescence.