Autoradiographic Localization of Radioactivity in Rat Brain after Injection of Tritiated Sex Hormones

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Science  27 Sep 1968:
Vol. 161, Issue 3848, pp. 1355-1356
DOI: 10.1126/science.161.3848.1355


Radioactivity was found in cell bodies of neurons and glial cells throughout brains of male and female rats that had been injected with either testosterone-H3 or estradiol-H3. Uptake by limbic and hypothalamic structures was higher and longer lasting than that in nonlimbic structures. In all brains, the preoptic area, prepiriform cortex, olfactory tubercle, and septum had particularly high, long-lasting uptake of both hormones.

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