Herpes Simplex Virus in Mice: Electron Microscopy of Neural Spread

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Science  04 Oct 1968:
Vol. 162, Issue 3849, pp. 126-127
DOI: 10.1126/science.162.3849.126


Herpes simplex virus rapidly infected the trigeminal nerves of mice after intranasal inoculation. Centripetal neural spread was suggested by histologic evidence of encephalitis in the area of attachment of the trigeminal nerve. Furthermore, electron microscopy revealed virus replication primarily within Schwann cells of the trigeminal nerve, and neurons of the gasserian ganglion.

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