Brain Alcohol Dehydrogenase

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Science  04 Oct 1968:
Vol. 162, Issue 3849, pp. 131-132
DOI: 10.1126/science.162.3849.131


Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural disorders associated with chronic alcohol ingestion or withdrawal.

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